Penetration Testing: Assessing a machine with 2 NICs

[barcajax () gmail com]

Lets say we have a machine running critical business applications connected to the enterprise network on 2 NICs. From 
an assessment/audit point of view, is it necessary to scan both NICs using assessment tools like NMap and Nessus? Will 
both scan results produce the same findings (as in same ports and services open)?
Does the OS or applications influence the detection of ports/services on different NICs on the same physical machine?

------------------------------------------------------------------------------
Audit your website security with Acunetix Web Vulnerability Scanner: 

Hackers are concentrating their efforts on attacking applications on your 
website. Up to 75% of cyber attacks are launched on shopping carts, forms, 
login pages, dynamic content etc. Firewalls, SSL and locked-down servers are 
futile against web application hacking. Check your website for vulnerabilities 
to SQL injection, Cross site scripting and other web attacks before hackers do! 
Download Trial at:

http://www.securityfocus.com/sponsor/pen-test_050831
-------------------------------------------------------------------------------