Can a prefix be never routed on Internet but used only for source address in IP packets?

["Sriram, Kotikalapudi (Fed) via NANOG" <nanog () lists nanog org>]

Question:  Can a prefix be never routed on the Internet but used only one-way for source address in IP packets? 

That is. a user owns an IP prefix. They never advertise a route to it in BGP on the Internet. But they use the prefix 
solely for source address in IP traffic from a source to a destination (sink).  In this set up, the destination server 
obviously cannot/doesn't return any acknowledgements etc. to the source.  Anyone aware if there is any such known 
application in use on the Internet - even if it is rare? Thanks.

Sriram 
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